Studies in natural product chemistry-Bioactive Natural Products

Studies in natural product chemistry Volume 25 Bioactive Natural Products (Part F)

Chemical Nature books

Studies in Natural Products Chemistry edited by Atta-ur-Raliman

Vol. 1 Stereoselective Synthesis (Part A)
Vol. 2 Structure Elucidation (Part A)
Vol. 3 Stereoselective Synthesis (Part B)
Vol. 4 Stereoselective Synthesis (Part C)
Vol. 5 Structure Elucidaton (Part B)
Vol. 6 Stereoselective Synthesis (Part D)
Vol. 7 Structure and Chemistry (Part A)
Vol. 8 Stereoselective Synthesis (Part E)
Vol. 9 Structure Chemistry (Part B)
Vol. 10 Stereoselective Synthesis (Part F)
Vol. 11 Stereoselective Synthesis (Part G)
Vol. 12 Stereoselective Synthesis (Part H)
Vol. 13 Bloactive Natural Products (Part A)
Vol. 14 Stereoselective Synthesis (Part I)
Vol. 15 Structure and Chemistry (Part C)
Vol. 16 Stereoselective Synthesis (Part J)
Vol. 17 Structure and Chemistry (Part D)
Vol. 18 Stereoselective Synthesis (Part K)
Vol. 19 Structure and Chemistry (Part E)
Vol. 20 Structure and Chemistry (Part F)
Vol. 21 Bloactive Natural Products (Part B)
Vol. 22 Bloactive Natural Products (Part C)
Vol. 23 Bloactive Natural Products (Part D)
Vol. 24 Bloactive Natural Products (Part E)
Vol. 25 Bloactive Natural Products (Part F)

Studies in natural product chemistry Volume 25Bioactive Natural Products (Part F)

FOREWORD

The present volume of Studies in Natural Product Chemistry covers many important

classes of bioactive natural products. The article on bloactive indole alkaloids by Reija

Jokela et. al., describes the acid-catalysed epimerization of these compounds and

resulting pharmacological activities. Toshihiro Akihisa & Ken Yasukawa present the

antitumor-promoting and anti-inflammatory activities of triterpenoids and sterols from

plants and fungi, many of which are of medicinally importance. A number of articles on

bioactive terpenes Include oleanene glucuronides (James Kinjo et. al.,) biotransformation

of terpenoids by microorganisms (Jan C.R. Demyttenaere), cycloartane and oleanane

saponins (Luisella Yerotta et, al.,) and labdane-type diterpenes (Cost as Demetzoo et.

al.,) as well as metabolism of the tomato saponin alpha-tomatine by phytopathogenic

fungi (Manuel Ruiz-Rubio et. al.,). An interesting article has been written by James

Zlegler, et. al.,) on heme aggregation inhibitors. Intercellular communication in higher

plants continues to be of interest and in addition to the known phytoharmones i.e. auxins,

cytokinins, gibberellins, abscisic acid and ethylene, certain bioactive peptides have been

identified in signal transductions involved In plant defence, growth and development

which is discussed by Andreas Schaller. The articles on the biosynthesis of

brassinosteroids by Jochen Winter, immunopotentlating effects of a glycoprotein from

Chlorella vulgaris by Kuniaki Tanaka et. al. and hepatoprotective plants components by

Shiegeoshi Kadota et. al., should also be of considerable interest. The induction and

regulation of biosynthetic activity of phytoalexins in carrot cells is reviewed by Fumiya

Kurosaki. The plant inhibition of eukaryote signal transduction induced by secondary

metabolites is another important area which is comprehensively described by Gideon M.

Polya. Two articles written by Juan Duarte et. al., & J. Galvez et. al., cover the important

effects of flavonoids on cardiovascular and gastrointestinal disorders respectively, while

the bioactivity of phenolic componds in higher plants is described by Juan M. Ruiz et. al.

Marine substances continue to be important sources of bioactive natural products.

Recent advances in marine natural products are covered by M.J. Abad et. al., in detail.

Biologically active halogen compounds described by Gerhard Laus and marine sulfurcontaining

natural products reviewed by Carolos Jimenez and biological activities

chlorogenic acids discussed by Motoyo Ohnishi et. al., should also be of interest to the

readers. Ethanolic extracts of Crocus sativus and Its components in learning behaviour

and long term potentiation of memory processes is another recent area of interest which

has been reviewed by Y. Shoyama et. al.,).

It is hoped that Volume-25 of "Studies in Natural Products Chemistry" would prove to be

of considerable interest to the readers and represent important another additions this

growing series books natural product chemistry.

I would like to express my thanks to Dr. Shakeel Ahmad for his assistance in the

preparation of the index. I am also grateful to Mr. Muhammad Asif and Mr. Waseem

Ahmad for typing and to Mr. Mahmood Alam for secretarial assistance.

Atta-ur-Rahman

Ph.D. (Cantab), SaD. (Can)

CONTENTS

• Acid-catalysed epimerization of bioactive indole alkaloids and their derivatives
• Antitumor-promoting and anti-inflammatory activities of triterpenoids and sterols fi'om plants and fungi
• Bioactive oleanene glucuronides obtained from fabaceous plants
• Biotransformation of terpenoids by microorganisms
• Cycloartane and oleanane saponins from Astragalus sp.
• Labdane-type diterpenes: Chemistry and biological activity
• Metabolism of the tomato saponin a-tomatine by phytopathogenic fungi
• Heme aggregation inhibitors: Antimalarial drugs targeting an essential biomineralization process
• Bioactive peptides as signal molecules in plant defense, growth and development
• Enzymes involved in the biosynthesis of brassinosteroids
• Immunopotentiating effects of a glycoprotein from Chlorella vulgaris strain CK and its characteristics
• Hepatoprotective effect of plant components: Inhibition of tumor necrosis Factor-ot-dependent inflammatory liver injury
• Induction and regulation of biosynthetic activity of phytoalexin in carrot cells
• Inhibition of Eukaryote Signal Transduction Components by
• Plant Defensive Secondary Metabolites
• Flavonoids and cardiovascular diseases
• Effects of flavonoids on gastrointestinal disordersJ.
• Bioactivity of the phenolic compounds in higher plants
• Bioactive natural products from marine sources
• Biological activities of natural halogen compounds
• Marine sulfur-containing natural products
• Absorption, metabolism and biological activities of chlorogenic acids and related compounds
• Effects of ethanol extract of Crocus sativus L. and its components on learning behavior and long-term potentiation

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