Burger's Medicinal Chemistry and Drug Discovery Volume 1 (Sixth Edition) Edited by Donald J. Abraham
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Content of volume 1
Methods in Drug Discovery.
History of Quantitative Structure Activity Relationships.
Mass spectrometry and drug discovery.
Chirality and Biological Activity.
Analog design.
SNPs: Single Nucleotide Polymorphisms and Pharmacogenomics - individually designed drug therapy.
Design of peptidomimetics.
Dual Acting Drugs.
Combinational chemistry and multiple parallel synthesis.
Allosteric proteins and drug discovery.
Principles of drug metabolism.
Pharmacophore-based drug design.
Use of biological fingerprints vs Structure/chemotypes to describe molecules.
Recent advances in development, validation and exploitation of QSAR models.
The Application of recombinant DNA Technology in medicinal chemistry and drug discovery.
Structural genomics, its application in Chemistry, Biology, Medicine, and Drug Discovery.
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