Analysis and Purification Methods in Combinatorial Chemistry By Bing Yan

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Content of Analysis and Purification Methods in Combinatorial Chemistry By Bing Yan

PART I: ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS 1

CHAPTER 1: QUANTITATIVE ANALYSIS IN ORGANIC SYNTHESIS WITH NMR
SPECTROSCOPY 3
Laura H. Lucas and Cynthia K. Larive

CHAPTER 2: 19F GEL-PHASE NMR SPECTROSCOPY FOR REACTION MONITORING AND QUANTIFICATION OF RESIN LOADING 37
Joseph M. Salvino

CHAPTER 3: THE APPLICATION OF SINGLE-BEAD FTIR AND COLOR TEST FOR REACTION
MONITORING AND BUILDING BLOCK VALIDATION IN COMBINATORIAL LIBRARY SYNTHESIS 53
Jason J. Cournoyer, Clinton A. Krueger, Janice V.Wade,
and Bing Yan

CHAPTER 4: HR-MAS NMR ANALYSIS OF COMPOUNDS ATTACHED TO POLYMER SUPPORTS 71
Meritxell Guinó and Yolanda R. de Miguel
v
CHAPTER 5: MULTIVARIATE TOOLS FOR REAL-TIME MONITORING AND OPTIMIZATION OF COMBINATORIAL MATERIALS AND PROCESS CONDITIONS 87
Radislav A. Potyrailo, Ronald J. Wroczynski,
John P. Lemmon,William P. Flanagan,
and Oltea P. Siclovan
CHAPTER 6: MASS SPECTROMETRY AND SOLUBLE POLYMERIC SUPPORT 125
Christine Enjalbal, Frederic Lamaty, Jean Martinez,
and Jean-Louis Aubagnac

PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL 137

CHAPTER 7: HIGH-THROUGHPUT NMR TECHNIQUES FOR COMBINATORIAL CHEMICAL
LIBRARY ANALYSIS 139
Ting Hou and Daniel Raftery
CHAPTER 8: MICELLAR ELECTROKINETIC CHROMATOGRAPHY AS A TOOL FOR
COMBINATORIAL CHEMISTRY ANALYSIS: THEORY AND APPLICATIONS 175
Peter J. Simms
CHAPTER 9: CHARACTERIZATION OF SPLIT-POOL ENCODED COMBINATORIAL
LIBRARIES 209
Jing Jim Zhang and William L. Fitch

PART III: HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY 253

CHAPTER 10: STRATEGIES AND METHODS FOR PURIFYING ORGANIC COMPOUNDS
AND COMBINATORIAL LIBRARIES 255
Jiang Zhao, Lu Zhang, and Bing Yan
vi contents

CHAPTER 11: HIGH-THROUGHPUT PURIFICATION: TRIAGE AND OPTIMIZATION 281
Jill Hochlowski

CHAPTER 12: PARALLEL HPLC IN HIGHTHROUGHPUT ANALYSIS AND PURIFICATION 307
Ralf God and Holger Gumm

PART IV :ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY 321

CHAPTER 13: ORGANIC COMPOUND STABILITY IN LARGE, DIVERSE PHARMACEUTICAL
SCREENING COLLECTION 323
Kenneth L. Morand and Xueheng Cheng

CHAPTER 14: QUARTZ CRYSTAL MICROBALANCE IN BIOMOLECULAR RECOGNITION 351
Ming-Chung Tseng, I-Nan Chang, and Yen-Ho Chu

CHAPTER 15: HIGH-THROUGHPUT PHYSICOCHEMICAL PROFILING: POTENTIAL AND
LIMITATIONS 369
Bernard Faller

CHAPTER 16: SOLUBILITY IN THE DESIGN OF COMBINATORIAL LIBRARIES 407
Christopher Lipinski

CHAPTER 17: HIGH-THROUGHPUT DETERMINATION OF LOGDVALUES BY LC/MS METHOD
Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt Jr.,
and James J. Bao
INDEX 457

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